An estimated 56,000 persons in the United States become infected with HIV every year. Of the 1.1 million persons living with HIV in the United States, approximately 250,000 are not aware of their infection and their risk for transmitting HIV to others. Of those who are unaware, many are diagnosed late in the course of their infection, after a prolonged asymptomatic period during which further transmission may have occurred. Persons who are diagnosed late in their infection miss a valuable opportunity to start HIV care and are at greater risk for AIDS-related complications (than those diagnosed earlier). Therefore, it should […]
Is that Drug Really Necessary?
A recent Boston Globe article described a large settlement a family won against Johnson & Johnson, the maker of Children’s Motrin. There’s an old adage, “All I know is what I read in the newspaper” and that is the case here. While it may sound like a windfall for the family, there was more to the story than just suing for—and winning—millions of dollars, and there is no happy ending nor winner. According to the article, when a little girl was seven years old her parents gave her Children’s Motrin for a fever. She apparently received three doses over 24 […]
Gender-Specific Medicine: Part 2
This week we continue to look at gender medicine- how diseases may manifest themselves differently, and how medications may affect differently- depending on whether you are male or female. An editorial in Nature in 2010 urged us to “put Gender on the Agenda,” as increasingly we are seeing from research results that there are distinct gender-based differences in disease incidence and activity, and treatment methods, especially medication. Cancer, for example, is the second leading cause of death among women and men, (Anderson, R.N., Deaths: Leading Causes for 2000. National Vital Statistics Reports. 2002, National Center for Health Statistics: Hyattsville, MD), […]
Gender-Specific Medicine
“Women are from Venus, Men are from Mars.” “Women think differently than men.” These viewpoints appear to be widespread and popular, fueling spirited and on-going debate in the media and the arts, but what about healthcare and medicine? Most medical research over the years has focused on white men as subjects, and results were then extrapolated to include everyone else. From an ethical perspective, there were some humanistic reasons for this, e.g., protecting women and children from experimental research that may not have benefited them. In many cases, however, research focused on those in positions of power. This situation is slowly […]
The Lowdown on Specialty Drugs II: Biosimilars and How to Get Your Insurance Company to Cover the Costs
Biosimilars are defined as “similar versions of an existing biological medicine by a different manufacturer.” Biosimilars may be used to treat difficult-to-manage conditions including rheumatoid arthritis, multiple sclerosis, chronic pain, HIV and cancer, among other conditions. Because they are more complex and more difficult to manufacture than other pharmaceuticals, rigid compliance to regulations and quality control are crucial to avoid contamination and drug shortages. Their complexity also means that they are more expensive for the patient. A recent article by NBC News suggests that “the number of patients who could benefit from these more sophisticated therapies will only continue to […]