How To Pay Less For Entreso — With Or Without Insurance

Last Updated on March 31, 2025

For many patients, the cost of Entresto makes managing heart failure even more challenging. While Entresto is a widely prescribed medication for heart failure treatment, its high price leaves many struggling to afford it. However, financial relief is available through Entresto savings programs, which help lower out-of-pocket expenses and improve access to this essential medication.

This guide explains what makes Entresto unique, why it’s expensive, and how to save money on your prescription. Whether through manufacturer discounts or patient assistance programs, there are ways to pay less than $10 per prescription.

What makes Entresto unique (and expensive)

Entresto (sacubitril/valsartan) is used to treat heart failure with reduced ejection fraction (HFrEF). It combines two active ingredients: sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. This combination enhances heart function by relaxing blood vessels and reducing fluid retention, thereby lowering the risk of hospitalization and heart-related complications.

A cheaper generic for Entresto won’t be available until at least July 2025, which marks the end of its patent protections. In the meantime, patients can take advantage of official savings programs offered by its manufacturer, Novartis. These programs help lower the cost for eligible patients.

3 Ways To Save On Entresto

Novartis offers the following programs for patients who take Entresto:

  • $10 Co-Pay Offer: If you have commercial (private) insurance, you may be able to pay as little as $10 by signing up for this Entresto coupon. By signing up for the Entresto $10 co-pay card, you will save up to $4,100 per year. Just bring the card to your pharmacy when filling your prescription.
  • Mail-Order Reimbursement: If you use a mail-order pharmacy, check if they accept the co-pay card. If they don’t, you can still get reimbursed for your savings. Request a rebate form and send it in along with your pharmacy receipt, and you’ll receive the savings by mail.
  • 30-Day Free Trial Offer: For those just starting, Novartis offers a free trial for Entresto to help you begin treatment without worrying about the cost. Just ask your doctor for the trial offer and bring it to a participating pharmacy. This offer is available regardless of insurance coverage.

To learn more about these programs, visit Entresto’s website.

How To Get Entresto For Free

For those who cannot afford Entresto, the Novartis Patient Assistance Program may provide it at no cost. To qualify, you must:

  • Be uninsured or have Medicare or government-sponsored insurance.
  • Meet income requirements.
  • Live in the United States and receive treatment from a licensed healthcare provider.

If you think you qualify, you’ll need to complete an application with help from your doctor. Patient Assistance Programs can be difficult to navigate, but NeedyMeds provides resources to help make the process easier. Visit our website to learn what you need for a successful application.

NeedyMeds Can Help You Save On Medication Costs

At NeedyMeds, we connect patients with resources to make medications like Entresto more affordable. Whether you’re looking for manufacturer discounts, patient assistance programs, or other savings options, we provide the information you need to access lower-cost prescriptions.

Visit NeedyMeds.org to explore available savings options and take control of your medication costs today.

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Welcome to the NeedyMeds Voice! We look forward to presenting you with timely, provocative pieces on healthcare reform, patient advocacy, medication and healthcare access, and other health-related news. Our goals are to educate, enlighten, and elucidate; together, we will try to make sense of the myriad and ongoing healthcare-related changes in the U.S. today.