Last Updated on May 13, 2025
For many patients, the cost of Entresto makes managing heart failure even more challenging. While Entresto is a widely prescribed medication for heart failure treatment, its high price leaves many struggling to afford it. However, financial relief is available through Entresto savings programs, which help lower out-of-pocket expenses and improve access to this essential medication.
This guide explains what makes Entresto unique, why it’s expensive, and how to save money on your prescription. Whether through manufacturer discounts or patient assistance programs, there are ways to pay less than $10 per prescription.
What Is Entresto?
Entresto (sacubitril/valsartan) is used to treat heart failure with reduced ejection fraction (HFrEF). It combines two active ingredients: sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. This combination enhances heart function by relaxing blood vessels and reducing fluid retention, thereby lowering the risk of hospitalization and heart-related complications.
The FDA approved Entresto after strong clinical evidence showed its ability to improve survival and reduce the need for hospital stays in people with HFrEF. Healthcare providers usually prescribe it when symptoms persist despite standard treatment. Because of its proven benefits, the drug has become a go-to option in many treatment plans.
How Much Does Entresto Cost Without Insurance?
Entresto is one of the more expensive prescription drugs used to manage heart failure. Without insurance, a 30-day supply often costs between $600 and $700, depending on the pharmacy and dosage. These out-of-pocket costs can place a significant financial strain on individuals who rely on the medication long term.
A cheaper generic won’t be available until at least July 2025, which marks the end of its patent protections. In the meantime, patients can take advantage of official savings programs offered by its manufacturer, Novartis. These programs help lower the cost for eligible patients.
3 Ways To Save On Entresto If you have insurance
Novartis offers the following programs for patients who take Entresto:
- Entresto $10 Co-Pay Card: If you have commercial (private) insurance, you may be able to pay as little as $10 by signing up for this Entresto coupon. By signing up for the Entresto $10 co-pay card, you will save up to $4,100 per year. Just bring the card to your pharmacy when filling your prescription.
- Mail-Order Reimbursement: If you use a mail-order pharmacy, check if they accept the co-pay card. If they don’t, you can still get reimbursed for your savings. Request a rebate form and send it in along with your pharmacy receipt, and you’ll receive the savings by mail.
- Entresto Free Trial: Whether you have insurance or not, Novartis offers free Entresto for up to a month. This can be a useful program if you’re waiting for approval or are trying the medication.
To learn more about these programs, visit Entresto’s website.
Does Medicare Cover Entresto?
Medicare Part D does cover Entresto, but your cost will depend on your specific plan. Some plans place Entresto on a higher tier, which may result in higher copays. However, if you have limited income and resources, you may qualify for Extra Help, a Medicare program that lowers prescription costs.
Starting in 2025, Extra Help eliminates your Part D premium and deductible. You’ll pay no more than $4.90 for generics and $12.15 for brand-name drugs. Once your total drug spending reaches $2,000, you won’t pay anything for covered prescriptions for the rest of the year.
You may automatically qualify for Extra Help if you receive full Medicaid, help from your state to pay Medicare Part B premiums, or Supplemental Security Income (SSI). Others will need to apply through the Social Security Administration.
If you’re not sure whether you qualify, contact your local Medicaid office or State Health Insurance Assistance Program (SHIP) for free guidance.
How To Get Entresto For Free Without Insurance
For those who cannot afford Entresto, the Novartis Patient Assistance Foundation (NPAF) provides it for free to eligible patients. To qualify, you must:
- Be uninsured, have Medicare or government-sponsored insurance.
- Be under the care of a licensed healthcare provider
- Live in the United States
You’ll also need to meet income requirements and submit the first two pages of your most recent tax return as proof. You must complete the application with your healthcare provider and sent to NPAF by mail or fax. Be sure to submit everything together because incomplete or missing information can delay or prevent approval.
If the NPAF approves your application, they will contact you to schedule delivery of your first shipment. The program delivers most medications directly to your home, unless your doctor administers them in-office. Processing generally takes up to four weeks, though it may take longer during busy periods.
If the NPAF denies your application, you may be able to submit a Denial Appeal Application or contact NPAF to discuss changes in your situation.
Watch Out for Costly Application Assistance Scams
Be cautious of companies that claim to submit Patient Assistance Program (PAP) applications on your behalf. They can charge between $70-90 during the application process, and they often continue billing even after you’ve received the medication. In some cases, they may tell you that a PAP is available when none exists. That means they charge you monthly while you receive nothing in return.
On our website, you’ll find trusted application assistance programs run by clinics, nonprofits, or pharmacies that provide this support for free or at a very low cost. Some may charge a small one-time or monthly administrative fee (typically under $10) but most are entirely free and transparent. Staff can help you complete paperwork, verify your eligibility, and guide you through the application process from start to finish.
Visit our site to find an application assistance program near you and avoid high costs.
NeedyMeds Can Help You Save On Medication Costs
At NeedyMeds, we connect patients with resources to make medications more affordable. Whether you’re looking for manufacturer discounts, patient assistance programs, or other savings options, we provide the information you need to access lower-cost prescriptions.
Visit NeedyMeds.org to explore available savings options and take control of your medication costs today.
