Last Updated on July 9, 2025
In June 2025, the U.S. Food and Drug Administration (FDA) approved Yeztugo (lenacapavir), which is the first and only twice-yearly injection for HIV prevention. This means that people at risk for HIV can now get long-acting protection with just two injections per year.
NeedyMeds understands that new medicines often comes with high price tags. That’s why we keep track of any manufacturer savings program we can find, and allow them to be easily searchable on our website.
Thankfully, Gilead, the manufacturer of Yeztugo, offers programs that can significantly reduce or even eliminate the cost. In this blog, we’ll talk about the programs we know about that can help lower the cost of Yeztugo.
What Is Yeztugo?
Yeztugo is a new, long-acting injectable used for pre-exposure prophylaxis (PrEP), which is a method of preventing HIV. Unlike daily oral medications, Yeztugo is given as an injection once every six months, offering year-round protection with just two doses per year. It works by targeting the HIV capsid protein, disrupting the virus’s ability to replicate and infect cells.
This makes Yeztugo a compelling option for people who prefer not to take daily pills or want a more discreet and low-maintenance way to prevent HIV. But being a new drug comes with a high cost.
How Much Does Yeztugo Cost?
The list price for Yeztugo is approximately $28,218 per year, which includes the oral and injectable components. Without insurance or assistance, this price is likely out of reach for many.
However, Gilead offers two major ways to reduce or eliminate the cost. These programs will help you afford Yeztugo regardless of insurance coverage.
Is There A Co-Pay Savings Program For Yeztugo?
If you have private insurance, you may qualify for help covering your out-of-pocket costs through the Yeztugo Co-pay Savings Program. Most eligible patients will pay nothing, but depending on your insurance coverage you may pay up to $25 at the most.
At a glance, this program:
- Provides up to $8,000 per calendar year in support
- Covers up to $100 per injection visit, with no monthly limit
- Can be used toward co-pays, co-insurance, and other eligible out-of-pocket expenses
To qualify, you must have commercial insurance and a valid prescription. You may be asked to provide documentation, such as proof of insurance or income, to confirm eligibility.
To stay informed on all offers, we encourage you to follow our Yeztugo coupon page for updates.
How Can I Afford Yeztugo Without Insurance?
If you don’t have insurance, you may be eligible to receive it for free through Gilead’s Medication Assistance Program (MAP). This program provides HIV prevention medication at no cost to qualified individuals.
- You must be a resident of the U.S., Puerto Rico, or a U.S. territory and meet income and insurance-related eligibility criteria
- A healthcare provider must complete part of the application, including the prescription and required signatures
- Medication is shipped overnight by FedEx to the location of your choice, such as your home, provider’s office, shelter, or a FedEx pick-up site
You can apply online for an instant decision, or submit a paper application by fax and receive a response within two business days. Enrollment lasts up to 12 months, with an option to reapply if you still qualify. If you become eligible for Medicaid or ADAP during your enrollment, you may not be able to renew.
To learn everything you need to know about the Yeztugo MAP, visit our page here.
Final Thoughts
Yeztugo offers a game-changing option in HIV prevention with its twice-yearly dosing.
But innovation comes at a cost, and that’s where financial assistance programs can make all the difference. NeedyMeds can connect you to this and other programs that can help with out-of-pocket costs.
Whether you’re insured or uninsured, there are programs that can help can help reduce the financial burden or cover the cost entirely. If you still unsure what you qualify for, call us at 800-503-6897.
